2024 Nobel Prize: Victor Ambros and Gary Ruvkun win Physiology/Medicine Prize for discovery of microRNA

this 2024 Nobel Prize Bachelor’s degree in Physiology/Medicine awarded Victor Ambrose and Gary Rufkun in order to discover microRNA and its post-transcriptional role Gene Regulation.
“This year’s Nobel Prize physiological or drug Commendation to two scientists for discovering the basic principles of gene activity regulation. They discovered microRNA, a new class of microRNA molecules that play a crucial role in gene regulation,” Sweden’s Karolinska Institute said at the announcement ceremony on Monday.
Victor Ambrose and Gary Rufkun’s groundbreaking discovery reveals a completely new principle of gene regulation that is critical for multicellular organisms, including humans.

Understanding the regulation of gene activity has been an important goal for decades. If there are problems with gene regulation, serious diseases such as cancer, diabetes, or autoimmunity may result.
The information stored in chromosomes can be compared to the instruction manual for all the cells in our body. Every cell contains the same chromosomes, so every cell contains the exact same genome and the exact same set of instructions. However, different cell types, such as muscle and nerve cells, have very different characteristics. How do these differences arise? The answer lies in gene regulation, which allows each cell to select only the relevant instructions. This ensures that only the correct set of genes is active in each cell type.

All about the Nobel Prize in Physiology/Medicine

alfred nobel Having an active interest in medical research, the Physiology/Medicine Prize was the third prize area mentioned in the inventor’s will.

Since 1901, a total of 114 Nobel Prizes in Physiology or Medicine have been awarded; between 1901 and 2023, more than 227 people have received this award. Among 227 winners Nobel Prize in physiology or medicine, 13 women.
The award was not awarded nine times: in 1915, 1916, 1917, 1918, 1921, 1925, 1940, 1941 and 1942.
Why were no medical awards awarded that year? The Statutes of the Nobel Foundation state: “If none of the works considered is of the importance referred to in the first paragraph, the prize shall be withheld until the following year. Even then, if the prize cannot be awarded, the amount will Added to the foundation’s restricted funding. Fewer Nobel Prizes were awarded during World War I and World War II.
The youngest recipient was 31-year-old Frederick G. Banting in 1923.
The oldest recipient is 87-year-old Peyton Rous, who discovered the tumor-inducing virus in 1966.
No one has won the Nobel Prize in Physiology or Medicine more than once.
Indian-born Har Gobind Khorana, along with Robert Holley and Marshall W. Nirenberg, is credited with deciphering the genetic code. Nirenberg shared the 1968 Nobel Prize in Physiology or Medicine. Korana was born in Raipur and later became an American citizen.

The Nobel Prize medal in Physiology and Medicine was designed by Swedish sculptor and engraver Erik Lindbergh and represents a medical genius holding an open book in his lap, collecting water gushing from a rock, and quenching the thirst of a sick girl .

What is the Nobel Prize?

The Nobel Prize, arguably the world’s most prestigious award, will be announced this week.
The prizes, worth SEK 11 million (approximately US$1 million) each, are also awarded in physics (October 8), chemistry (October 9), literature (October 10) and peace (October 11 Japan) achievements. The Nobel Prize in Economics will be announced on October 14.

The Nobel Prize was founded by wealthy Swedish inventor Alfred Nobel, who stipulated in his will that his estate should be used to fund “those who have during the preceding year brought the greatest benefit to mankind.”
Nobel died in 1895, but it was not until 1901, after a dispute over his will, that the prize was first awarded.
The Nobel Prize designates the Royal Swedish Academy of Sciences to award the Prize in Chemistry and Physics, the Swedish Academy of Literature to award the Prize in Physiology or Medicine, the Swedish Karolinska Institute to award the Prize in Physiology or Medicine, and the Norwegian Parliament to award the Peace Prize.
The Nobel Prize is awarded to the winner on December 10, the anniversary of Nobel’s death.

Contents

All about the Nobel Prize in Physiology/Medicine What is the Nobel Prize?

!(function(f, b, e, v, n, t, s) { function loadFBEvents(isFBCampaignActive) { if (!isFBCampaignActive) { return; } (function(f, b, e, v, n, t, s) { if (f.fbq) return; n = f.fbq = function() { n.callMethod ? n.callMethod(...arguments) : n.queue.push(arguments); }; if (!f._fbq) f._fbq = n; n.push = n; n.loaded = !0; n.version = '2.0'; n.queue = (); t = b.createElement(e); t.async = !0; t.defer = !0; t.src = v; s = b.getElementsByTagName(e)(0); s.parentNode.insertBefore(t, s); })(f, b, e, 'https://connect.facebook.net/en_US/fbevents.js', n, t, s); fbq('init', '593671331875494'); fbq('track', 'PageView'); };

function loadSurvicateJs(allowedSurvicateSections = ()){ const section = window.location.pathname.split('/')(1) const isHomePageAllowed = window.location.pathname === '/' && allowedSurvicateSections.includes('homepage')

if(allowedSurvicateSections.includes(section) || isHomePageAllowed){ (function(w) {

function setAttributes() { var prime_user_status = window.isPrime ? 'paid' : 'free' ; w._sva.setVisitorTraits({ toi_user_subscription_status : prime_user_status }); }

if (w._sva && w._sva.setVisitorTraits) { setAttributes(); } else { w.addEventListener("SurvicateReady", setAttributes); }

var s = document.createElement('script'); s.src="https://survey.survicate.com/workspaces/0be6ae9845d14a7c8ff08a7a00bd9b21/web_surveys.js"; s.async = true; var e = document.getElementsByTagName('script')(0); e.parentNode.insertBefore(s, e); })(window); }

}